Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655551 | 0.99 | GRIA4 (0.39) | GRIA4ALDH1A1LMNAPRNPRECQL | |
| SCHEMBL2655577 | 0.96 | GRIA4 (0.39) | GRIA4ALDH1A1LMNAPRNPRECQL | |
| SCHEMBL2655215 | 0.91 | PPARD (0.39) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL2655627 | 0.90 | PPARD (0.39) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL2652568 | 0.87 | PPARD (0.40) | PPARDPPARA | |
| SCHEMBL2652959 | 0.86 | GCGR (0.43) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL2653596 | 0.85 | GCGR (0.44) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL2658618 | 0.84 | GRIA4 (0.37) | GRIA4ALDH1A1GRIA2PTGER3PTGER2 | |
| SCHEMBL2653026 | 0.82 | GCGR (0.44) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL2655641 | 0.82 | GRIA4 (0.36) | GRIA4ALDH1A1GRIA2PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957484-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly & Company (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007120284-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-10-25 | — | — | WO | claimed |
| EP-1957484-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly & Company (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007120284-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-10-25 | — | — | WO | disclosed |