Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25283139 | 1.00 | APP (0.55) | APPALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL31079444 | 0.89 | KMT2A (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 | |
| SCHEMBL17002753 | 0.89 | KMT2A (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 | |
| SCHEMBL30288730 | 0.89 | KMT2A (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 | |
| SCHEMBL17002751 | 0.89 | KMT2A (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 | |
| SCHEMBL3920819 | 0.89 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 | |
| SCHEMBL3920813 | 0.89 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 | |
| SCHEMBL25141958 | 0.83 | APP (0.59) | APPALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL30487467 | 0.82 | TUBB1 (0.59) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 | |
| SCHEMBL20158247 | 0.82 | TUBB1 (0.59) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331663-A1 | SMALL MOLECULE NICOTINAMIDE ADENINE DINUCLEOTIDE MODULATORS | THE CLEVELAND CLINIC FOUNDATION | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230331663-A1 | SMALL MOLECULE NICOTINAMIDE ADENINE DINUCLEOTIDE MODULATORS | NQO1, NADK, CD38 | APP 2497/4885ALDH1A1 158/4885KDM4E 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.