Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10829519 | 0.75 | MAPT (0.35) | MAPTSMN1; SMN2ALDH1A1FDPSCYP19A1 | |
| SCHEMBL2659464 | 0.69 | CYP19A1 (0.36) | CYP19A1 | |
| SCHEMBL738419 | 0.66 | ALDH1A1 (0.50) | MAPTSMN1; SMN2ALDH1A1CYP19A1EGLN3 | |
| SCHEMBL6202347 | 0.64 | ALDH1A1 (0.38) | MAPTSMN1; SMN2ALDH1A1CYP19A1EGLN3 | |
| SCHEMBL25493018 | 0.63 | MEN1 (0.48) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL12564741 | 0.63 | MEN1 (0.38) | ALDH1A1FDPSCYP19A1EGLN3MEN1 | |
| SCHEMBL28302493 | 0.63 | ALDH1A1 (0.40) | MAPTSMN1; SMN2ALDH1A1CYP19A1EGLN3 | |
| SCHEMBL28336657 | 0.62 | CYP19A1 (0.42) | MAPTSMN1; SMN2ALDH1A1FDPSCYP19A1 | |
| SCHEMBL13245241 | 0.62 | MAPK1 (0.49) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL26045021 | 0.62 | CYP19A1 (0.43) | MAPTSMN1; SMN2ALDH1A1CYP19A1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333336-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTORS AS ANTICONVULSANTS FORMING THE COMPOUND BY AMIDATION | MERCK SHARP & DOHME LTD. (GB) | 2001-12-25 | — | — | US | disclosed |
| EP-1064283-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048892-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |