Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 7/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26571811 | 1.00 | HTR2A (0.33) | HTR2AHTR2CHTR2BHTR1ASLC6A2 | |
| SCHEMBL6177530 | 0.85 | HTR2A (0.36) | HTR2AHTR2CHTR2BHTR1ASLC6A2 | |
| SCHEMBL26572508 | 0.79 | OPRL1 (0.31) | — | |
| SCHEMBL26569513 | 0.79 | P2RX7 (0.45) | — | |
| SCHEMBL22854653 | 0.79 | P2RX7 (0.45) | — | |
| SCHEMBL26568819 | 0.79 | P2RX7 (0.45) | — | |
| SCHEMBL26568676 | 0.79 | P2RX7 (0.45) | — | |
| SCHEMBL26567574 | 0.78 | P2RX7 (0.35) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12206928 | 0.76 | HTR2A (0.31) | HTR2AHTR2CHTR2B | |
| SCHEMBL828712 | 0.76 | HTR2A (0.31) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609868-B1 | TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2023-10-18 | — | — | EP | disclosed |