Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204099 | 0.84 | LMNA (0.52) | HTTESR1MEN1KMT2ALMNA | |
| SCHEMBL22854944 | 0.84 | LMNA (0.52) | HTTESR1MEN1KMT2ALMNA | |
| SCHEMBL21985323 | 0.78 | PDE2A (0.58) | HTTESR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL22279501 | 0.78 | PDE2A (0.58) | HTTESR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL29472441 | 0.78 | PDE2A (0.58) | HTTESR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL10315782 | 0.74 | SLC6A4 (0.39) | HTTHTR2ASLC6A4KCNH2MEN1 | |
| SCHEMBL27842001 | 0.73 | HTT (0.38) | HTTESR1 | |
| SCHEMBL29519227 | 0.73 | LMNA (0.45) | HTTESR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL1911427 | 0.73 | LMNA (0.56) | HTTLMNATRPA1CHRM1SLC6A2 | |
| SCHEMBL673182 | 0.73 | LMNA (0.45) | HTTESR1HTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609868-B1 | TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2023-10-18 | — | — | EP | disclosed |