Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMYD3 | Q9H7B4 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083852 | 0.86 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL6775104 | 0.83 | NPC1 (0.45) | NPC1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL2116618 | 0.82 | HDAC6 (0.61) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL263941 | 0.80 | PARP1 (0.58) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL3984993 | 0.77 | NPC1 (0.64) | NPC1LMNASMYD3ALDH1A1HPGD | |
| SCHEMBL30265317 | 0.76 | NPC1 (0.81) | NPC1LMNASMYD3ALDH1A1HPGD | |
| SCHEMBL30205640 | 0.76 | PARP1 (0.57) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL13908150 | 0.76 | SLC2A1 (0.77) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL2315757 | 0.76 | PARP1 (0.57) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL265032 | 0.75 | PARP1 (0.56) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001875-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2008-12-17 | — | — | EP | claimed |
| WO-2007104034-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-09-13 | — | — | WO | claimed |