Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.58 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984997 | 0.89 | NPC1 (0.79) | NPC1LMNASMYD3MLLT1EPHX1 | |
| SCHEMBL5304873 | 0.88 | NPC1 (0.60) | NPC1LMNASMYD3ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL2356274 | 0.88 | NPC1 (0.60) | NPC1LMNASMYD3EPHX1ALDH1A1 | |
| SCHEMBL2352912 | 0.88 | NPC1 (0.54) | NPC1LMNASMYD3MLLT1EPHX1 | |
| SCHEMBL112516 | 0.86 | NPC1 (0.61) | NPC1LMNASMYD3ALDH1A1HPGD | |
| SCHEMBL8313317 | 0.85 | NPC1 (0.51) | NPC1LMNASMYD3MLLT1EPHX1 | |
| Hydrochloric Acid SCHEMBL2352408 | 0.84 | NPC1 (0.55) | NPC1LMNASMYD3HDAC6 | |
| Hydrochloric Acid SCHEMBL2351583 | 0.84 | NPC1 (0.55) | NPC1LMNASMYD3HDAC6 | |
| Hydrochloric Acid SCHEMBL2350435 | 0.84 | NPC1 (0.55) | NPC1LMNASMYD3HDAC6 | |
| SCHEMBL21489858 | 0.83 | SMYD3 (0.84) | NPC1LMNASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061786-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | Biogen Idec MA Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008030584-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN- 1 RECEPTOR-ASSOCIATED KINASE | BIOGEN IDEC MA INC. (US) | 2008-03-13 | — | — | WO | disclosed |