Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 19/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 16/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 13/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.53 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999952 | 0.85 | GABRG2 (0.65) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341740 | 0.85 | GABRG2 (0.79) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7001434 | 0.84 | GABRG2 (0.61) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2655690 | 0.83 | GABRG2 (0.69) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658157 | 0.83 | GABRG2 (0.61) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6997169 | 0.82 | GABRG2 (0.63) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341150 | 0.81 | GABRG2 (0.79) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2656092 | 0.81 | GABRG2 (0.59) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2661991 | 0.81 | GABRG2 (0.59) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL23554590 | 0.80 | GABRG2 (0.59) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LTD. (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012505-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |