Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 20/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 20/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216700 | 0.94 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2657650 | 0.92 | GABRA1 (0.56) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6218159 | 0.91 | GABRA1 (0.72) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6217338 | 0.85 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658039 | 0.83 | GABRA1 (0.85) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6218577 | 0.81 | BACE1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658836 | 0.80 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6215893 | 0.80 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6215587 | 0.78 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6216756 | 0.78 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381606-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2005-07-20 | — | — | EP | claimed |
| EP-1381606-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2005-07-20 | — | — | EP | disclosed |
| WO-2002074772-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-09-26 | — | — | WO | disclosed |