Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657924 | 0.81 | AKR1C4 (0.51) | GAAMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL646550 | 0.80 | GAA (0.47) | GAAMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL31525845 | 0.80 | NPC1 (0.50) | GAAMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2666277 | 0.77 | GAA (0.58) | GAAMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2367707 | 0.75 | GAA (0.47) | GAAMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4002584 | 0.74 | GAA (0.72) | GAAMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2656692 | 0.74 | MMP9 (0.38) | MAPTNPC1RAB9A | |
| SCHEMBL2647288 | 0.74 | MEN1 (0.38) | GAAMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9683164 | 0.73 | GAA (0.70) | GAAMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL23002819 | 0.73 | KDM4E (0.57) | GAAMAPTKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055130-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010055131-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010055131-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010055130-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |