Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657910 | 0.85 | GABRA1 (0.57) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2659150 | 0.82 | GABRA1 (0.53) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2656721 | 0.81 | GABRA1 (0.52) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2335595 | 0.81 | GABRA1 (0.67) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2337133 | 0.80 | GABRA1 (0.73) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2336126 | 0.80 | GABRA1 (0.72) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2338310 | 0.80 | GABRA1 (0.61) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2334885 | 0.79 | GABRA1 (0.53) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2658496 | 0.78 | GABRA1 (0.60) | GABRA1FGFR1GABRG2GABRB3GABRA5 | |
| SCHEMBL2656995 | 0.77 | GABRA1 (0.47) | GABRA1FGFR1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055129-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | claimed |