Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659314 | 0.86 | GCK (0.55) | GCK | |
| SCHEMBL1041008 | 0.77 | CA12 (0.44) | GCK | |
| SCHEMBL2656839 | 0.75 | GCK (0.55) | GCK | |
| SCHEMBL2655275 | 0.75 | GCK (0.43) | GCK | |
| SCHEMBL2658396 | 0.75 | CA12 (0.46) | HPGDSTSHR | |
| SCHEMBL2656378 | 0.75 | CA12 (0.46) | HPGDSTSHR | |
| SCHEMBL1040920 | 0.73 | GCK (0.54) | GCK | |
| SCHEMBL2074279 | 0.73 | GCK (0.48) | GCKHPGDS | |
| SCHEMBL2657797 | 0.73 | GCK (0.48) | GCKHPGDS | |
| SCHEMBL2086782 | 0.72 | GCK (0.65) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086964-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | Astra Zeneca AB (SE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008050101-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | ASTRAZENECA AB (SE) | 2008-05-02 | — | — | WO | disclosed |