Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.47 |
| ▸ | NQO2 | P16083 | 5/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809354 | 0.82 | ALDH1A1 (0.57) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL26581211 | 0.81 | HPGD (0.51) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL23809499 | 0.76 | KDM4E (0.47) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL27938424 | 0.76 | KDM4E (1.00) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL2905589 | 0.76 | ALDH1A1 (0.60) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL644451 | 0.75 | KMT2A (0.55) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL17099700 | 0.73 | HSD17B10 (0.52) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL26581347 | 0.70 | KDM4E (0.57) | KDM4EHPGDALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL2497506 | 0.69 | HSD17B10 (0.47) | KDM4EHPGDALDH1A1HSD17B10ATM | |
| SCHEMBL26039159 | 0.69 | KMT2A (0.39) | KDM4EHPGDALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885HPGD 3190/4885ALDH1A1 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.