Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | NAAA | Q02083 | 3/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768252 | 0.94 | TSHR (0.61) | TSHRTDP1L3MBTL1IDO1NAAA | |
| SCHEMBL4004770 | 0.91 | L3MBTL1 (0.58) | TSHRTDP1L3MBTL1IDO1NAAA | |
| SCHEMBL13643219 | 0.89 | L3MBTL1 (0.65) | TSHRTDP1L3MBTL1IDO1HRH4 | |
| SCHEMBL2657770 | 0.87 | TSHR (0.71) | TSHRTDP1IDO1NAAACHRM3 | |
| SCHEMBL8621469 | 0.87 | TSHR (0.70) | TSHRTDP1L3MBTL1IDO1NAAA | |
| SCHEMBL3686733 | 0.86 | TSHR (0.52) | TSHRTDP1L3MBTL1IDO1NAAA | |
| SCHEMBL9347610 | 0.85 | IDO1 (0.52) | TSHRTDP1L3MBTL1IDO1NAAA | |
| SCHEMBL26189830 | 0.85 | TSHR (0.67) | TSHRTDP1L3MBTL1IDO1NAAA | |
| SCHEMBL134086 | 0.85 | IDO1 (0.61) | TSHRIDO1CHRM3MAOB | |
| SCHEMBL21184508 | 0.83 | TSHR (0.64) | TSHRTDP1L3MBTL1IDO1NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129654-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | Metabasis Therapeutics, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008098244-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | METABASIS THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |