Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 1/20 | 0.67 |
| ▸ | BCR | P11274 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836981 | 0.83 | FLT3 (0.67) | FLT3PDGFRBABL1KITBCR | |
| SCHEMBL13753882 | 0.83 | SRC (0.65) | FLT3PDGFRBABL1KITBCR | |
| SCHEMBL25633255 | 0.82 | KDM4E (0.66) | FLT3KDM4EGAAALDH1A1MAPK1 | |
| SCHEMBL14653926 | 0.82 | KDM4E (0.64) | FLT3PDGFRBABL1KITBCR | |
| SCHEMBL15746114 | 0.82 | PIN1 (0.66) | FLT3PDGFRBKDM4EGAAALDH1A1 | |
| SCHEMBL4933623 | 0.82 | F7 (0.66) | KDM4EGAAALDH1A1MAPK1KMT2A | |
| SCHEMBL3282981 | 0.81 | FLT3 (0.73) | FLT3PDGFRBABL1KITBCR | |
| SCHEMBL2230377 | 0.80 | FLT3 (1.00) | FLT3PDGFRBABL1KITBCR | |
| SCHEMBL20478131 | 0.80 | FLT3 (0.58) | FLT3PDGFRBABL1KITBCR | |
| SCHEMBL2735968 | 0.80 | FLT3 (0.61) | FLT3PDGFRBABL1KITBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613942-B1 | Nonpeptide; 4-hydroxy benzoic acid hydrazides | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-0994848-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |