Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.54 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250416 | 0.85 | KDM4E (0.58) | KDM4ESMN1; SMN2ESR1ESR2TDP1 | |
| SCHEMBL26038140 | 0.84 | KDM4E (0.66) | KDM4ESMN1; SMN2PSMB1PSMB5PSMB2 | |
| SCHEMBL23771799 | 0.83 | LTA4H (0.53) | KDM4ESMN1; SMN2PSMB1PSMB5PSMB2 | |
| SCHEMBL13091445 | 0.81 | KDM4E (0.71) | KDM4ESMN1; SMN2PSMB1PSMB5PSMB2 | |
| SCHEMBL1251462 | 0.81 | KDM4E (0.55) | KDM4ESMN1; SMN2PSMB1PSMB5PSMB2 | |
| SCHEMBL14100107 | 0.80 | KDM4E (0.64) | KDM4EPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL13849370 | 0.79 | SMN1; SMN2 (0.63) | KDM4ESMN1; SMN2PSMB1PSMB5PSMB2 | |
| SCHEMBL19309962 | 0.78 | KDM4E (0.66) | KDM4ESMN1; SMN2ESR1ESR2HRH3 | |
| SCHEMBL2326590 | 0.78 | KDM4E (0.66) | KDM4ESMN1; SMN2ESR1ESR2HRH3 | |
| SCHEMBL82435 | 0.77 | HRH3 (0.73) | KDM4EPSMB1PSMB5PSMB2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885SMN1; SMN2 1682/4885PSMB1 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.