Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RARA | P10276 | 2/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657403 | 0.85 | GCK (0.40) | GCKKCNH2 | |
| SCHEMBL2657127 | 0.83 | MEN1 (0.59) | GCKMEN1KMT2A | |
| SCHEMBL2659053 | 0.82 | LMNA (0.47) | GCKMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2656678 | 0.82 | LMNA (0.47) | GCKMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2655778 | 0.80 | GCK (0.62) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL1427030 | 0.79 | GCK (0.75) | GCKRARARARBRARG | |
| SCHEMBL2656839 | 0.78 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL2659314 | 0.77 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL2657535 | 0.76 | GCK (0.48) | GCKRAB9ANPC1KCNH2 | |
| SCHEMBL1426977 | 0.75 | GCK (0.66) | GCKRARARARBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086964-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | Astra Zeneca AB (SE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008050101-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | ASTRAZENECA AB (SE) | 2008-05-02 | — | — | WO | disclosed |