Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 18/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001291 | 0.91 | GABRG2 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2658306 | 0.81 | GABRG2 (0.52) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6999782 | 0.71 | GABRG2 (0.46) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2659167 | 0.69 | GABRG2 (0.43) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7197657 | 0.68 | GABRG2 (0.54) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6999141 | 0.64 | GABRG2 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL5229593 | 0.64 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2658137 | 0.64 | GABRG2 (0.50) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2657570 | 0.64 | GABRG2 (0.53) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2659827 | 0.63 | GABRG2 (0.42) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212324-B1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-10-29 | — | — | EP | claimed |
| US-6608062-B1 | Ligands for gamma-aminobutyric acid receptors; treatment and/or prevention of central nervous system disorders, including anxiety | MERCK SHARP & DOHME LTD. | 2003-08-19 | — | — | US | claimed |
| EP-1212324-B1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-10-29 | — | — | EP | disclosed |
| US-6608062-B1 | Ligands for gamma-aminobutyric acid receptors; treatment and/or prevention of central nervous system disorders, including anxiety | MERCK SHARP & DOHME LTD. | 2003-08-19 | — | — | US | disclosed |
| EP-1212324-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014377-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |