Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.49 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225478 | 0.85 | CLEC4M (0.66) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL4742144 | 0.84 | KDM4E (1.00) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL2660023 | 0.81 | CYP1A2 (0.57) | KDM4EMAPTCYP1A2MEN1KMT2A | |
| SCHEMBL9635290 | 0.79 | CYP1A2 (0.66) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL29376920 | 0.79 | CYP1A2 (0.66) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL25208357 | 0.78 | CLEC4M (0.63) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL1353417 | 0.78 | KDM4E (0.61) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL1126279 | 0.78 | CLEC4M (0.78) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL4743455 | 0.77 | MEN1 (0.67) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 | |
| SCHEMBL29145962 | 0.77 | CLEC4M (0.62) | KDM4ECLEC4MMAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043930-A1 | QUINOLINE DERIVATIVES WHICH ENHANCE COGNITION VIA THE GABA-A RECEPTOR | MERCK SHARP & DOHME LIMITED (GB) | 2004-05-27 | — | — | WO | disclosed |