Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 7/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 11/20 | 0.39 |
| ▸ | GIPR | P48546 | 4/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.36 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765249 | 0.82 | GCGR (0.48) | GCGABL1BCRGCGRGIPR | |
| SCHEMBL2654487 | 0.78 | MEN1 (0.48) | GCGABL1BCRGCGRGIPR | |
| SCHEMBL2274002 | 0.77 | MAOB (0.49) | GCGABL1BCRGCGRGIPR | |
| SCHEMBL2271957 | 0.77 | GCGR (0.56) | GCGGCGRGIPRGLP1R | |
| SCHEMBL2662329 | 0.76 | MEN1 (0.49) | GCGABL1BCRGCGRGIPR | |
| SCHEMBL1765610 | 0.75 | GCGR (0.56) | GCGGCGRGIPRGLP1R | |
| SCHEMBL1765419 | 0.75 | GCG (0.57) | GCGGCGRGIPRGLP1R | |
| SCHEMBL2651240 | 0.75 | MAPT (0.48) | GCGABL1BCRGCGRGIPR | |
| SCHEMBL1765298 | 0.74 | GCG (0.58) | GCGGCGRGIPRGLP1R | |
| SCHEMBL2652464 | 0.74 | PPARD (0.44) | PPARDLMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |