Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2968477 | 0.85 | OXTR (0.32) | OXTRJAK2JAK1TYK2 | |
| SCHEMBL2967653 | 0.85 | OXTR (0.32) | OXTRJAK2JAK1TYK2 | |
| SCHEMBL2660404 | 0.85 | OXTR (0.32) | OXTRJAK2JAK1TYK2 | |
| SCHEMBL2660649 | 0.84 | — | — | |
| SCHEMBL2975450 | 0.84 | OXTR (0.30) | OXTR | |
| SCHEMBL2668694 | 0.84 | OXTR (0.31) | OXTRJAK2JAK1TYK2 | |
| SCHEMBL2968906 | 0.84 | OXTR (0.31) | OXTRJAK2JAK1TYK2 | |
| SCHEMBL13327398 | 0.83 | OXTR (0.30) | OXTR | |
| SCHEMBL2662013 | 0.83 | JAK2 (0.30) | JAK2JAK1TYK2 | |
| SCHEMBL2668889 | 0.83 | HTR2B (0.33) | JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2508524-A2 | Indole compound | Takeda Pharmaceutical Company Limited (JP) | 2012-10-10 | — | — | EP | disclosed |
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |