Leucine

Leucine

SCHEMBL26598008

CC(C)CC(N)C(=O)O.CC(C)CC(N)C(=O)O.CC(N)C(=O)O.CCC(C)C(N)C(=O)O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.64
SLC1A2 P43004 7/20 0.52
SLC1A3 P43003 6/20 0.52
SLC1A1 P43005 7/20 0.48
GRIK1 P39086 11/20 0.42
GRIK2 Q13002 8/20 0.42
DPP4 P27487 1/20 0.38
DPP8 Q6V1X1 1/20 0.38
DPP9 Q86TI2 1/20 0.38
GRIA4 P48058 3/20 0.37
GRIK3 Q13003 3/20 0.37
GRIK5 Q16478 3/20 0.37
GRIA2 P42262 2/20 0.36
GRIA1 P42261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL9721406 1.00 SLC7A5 (0.64) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL2551557 1.00 SLC7A5 (0.64) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL4294625 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
D-Leucine SCHEMBL1537398 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL1537205 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL3314487 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL122271 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL18249997 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL1537204 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL122270 0.96 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230343570-A1 Charge Reduced Mass Spectrometry for Sequencing of Oligonucleotide Therapeutics DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (SG) 2023-10-26 US disclosed