Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.56 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.56 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.36 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | ADH7 | P40394 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CASP2 | P42575 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28300170 | 0.82 | GNAI3 (0.70) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL8412464 | 0.82 | GNAI3 (0.70) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL28627512 | 0.82 | GNAI3 (0.70) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL28641324 | 0.82 | GNAI3 (0.70) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL28632179 | 0.82 | GNAI3 (0.70) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL8665131 | 0.80 | GNAI3 (0.67) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL8408732 | 0.78 | GNAI3 (0.66) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL9598276 | 0.78 | GNAI3 (0.66) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL6391709 | 0.78 | GNAI3 (0.66) | GNAI3GNAO1GNAI1EPHX1ADH1B | |
| SCHEMBL11179091 | 0.78 | GNAI3 (0.66) | GNAI3GNAO1GNAI1EPHX1ADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723128-A1 | HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005066145-A1 | HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-07-21 | — | — | WO | disclosed |