Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14873296 | 0.76 | HSD17B1 (0.58) | HSD17B1HSD17B2NPC1RAB9A | |
| SCHEMBL30957406 | 0.76 | HSD17B1 (0.68) | HSD17B1HSD17B2RAB9A | |
| SCHEMBL12266907 | 0.76 | MEN1 (0.49) | HSD17B1HSD17B2NPC1RAB9A | |
| SCHEMBL19152881 | 0.75 | KDM4E (0.47) | PDE4DPDE7AHSD17B1HSD17B2PDE3A | |
| SCHEMBL14873352 | 0.75 | HSD17B1 (0.61) | HSD17B1HSD17B2RAB9A | |
| SCHEMBL3882303 | 0.75 | PARP1 (0.49) | PARP1MAP2K4PDE4DPDE7AHSD17B1 | |
| SCHEMBL29441126 | 0.73 | FYN (0.49) | PARP1MAP2K4PDE4DPDE7AHSD17B1 | |
| SCHEMBL28322519 | 0.73 | FYN (0.49) | PARP1MAP2K4PDE4DPDE7AHSD17B1 | |
| SCHEMBL7369335 | 0.73 | CYP19A1 (0.56) | HSD17B1HSD17B2NPC1RAB9A | |
| SCHEMBL2431097 | 0.73 | PARP1 (0.64) | PARP1CCNT1CCND1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902052-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | AstraZeneca AB (SE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007007041-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |