Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26601327 | 1.00 | LMNA (0.34) | LMNALTB4RTP53TLR8TLR7 | |
| SCHEMBL26601306 | 0.78 | NPC1 (0.36) | SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL26601302 | 0.78 | NPC1 (0.36) | SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL26601318 | 0.74 | HDAC3 (0.44) | LMNASMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL10324410 | 0.70 | LMNA (0.54) | LMNANPSR1CYP1A2CYP2D6PKM | |
| SCHEMBL28465580 | 0.69 | LMNA (0.45) | LMNANPSR1CYP1A2CYP2D6PKM | |
| SCHEMBL2806858 | 0.68 | TP53 (0.39) | TP53TLR8TLR7NPSR1PKM | |
| SCHEMBL1528340 | 0.67 | TLR8 (0.56) | TP53TLR8TLR7 | |
| SCHEMBL30539927 | 0.67 | TLR8 (0.43) | LMNATLR8TLR7NPSR1CYP1A2 | |
| SCHEMBL10324369 | 0.66 | LMNA (0.56) | LMNANPSR1CYP1A2CYP2D6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023205219-A1 | PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS | BERG LLC (US) | 2023-10-26 | — | — | WO | disclosed |