Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.46 |
| ▸ | PLK4 | O00444 | 5/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | MARK3 | P27448 | 5/20 | 0.46 |
| ▸ | CLK2 | P49760 | 5/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696402 | 0.86 | JAK2 (0.55) | JAK2PDPK1NPC1RAB9ATYK2 | |
| SCHEMBL12881950 | 0.83 | NTRK1 (0.41) | JAK2NPC1MAPTRAB9AGFER | |
| SCHEMBL12881778 | 0.81 | NPC1 (0.40) | NPC1MAPTRAB9AGFERGSK3B | |
| SCHEMBL7214708 | 0.80 | JAK2 (0.56) | JAK2PDPK1TYK2JAK3ROCK1 | |
| Hydrochloric Acid SCHEMBL7214665 | 0.79 | JAK2 (0.55) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL14177539 | 0.79 | JAK2 (0.55) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL4542210 | 0.79 | JAK2 (0.59) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL2667981 | 0.78 | JAK2 (0.57) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL12031395 | 0.78 | JAK2 (0.50) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL12907094 | 0.78 | TBXAS1 (0.47) | JAK2PDPK1MAPTKDM4EJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966152-A2 | GLUCOKINASE ACTIVATORS | Takeda Pharmaceutical Company Limited (JP) | 2008-09-10 | — | — | EP | disclosed |
| US-20070244169-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-10-18 | — | — | US | disclosed |
| US-20070244169-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-10-18 | — | — | US | disclosed |
| US-20070244169-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-10-18 | — | — | US | disclosed |
| WO-2007075847-A2 | GLUCOKINASE ACTIVATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244169-A1 | GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | JAK2 2370/4885PDPK1 148/4885NPC1 2902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.