Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.50 |
| ▸ | TYK2 | P29597 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 3/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | MARK3 | P27448 | 3/20 | 0.44 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661665 | 0.80 | JAK2 (0.47) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL2662003 | 0.76 | GSK3B (0.43) | JAK2TYK2JAK3CLK4PRKD3 | |
| SCHEMBL2661889 | 0.74 | JAK2 (0.55) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL16934640 | 0.73 | JAK2 (0.58) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL16936129 | 0.71 | NTRK1 (0.55) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL3657599 | 0.71 | JAK2 (0.60) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL29521013 | 0.71 | JAK2 (0.60) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL10213929 | 0.70 | JAK2 (0.81) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL118573 | 0.70 | JAK2 (0.64) | JAK2PDPK1TYK2JAK3ROCK1 | |
| SCHEMBL2661165 | 0.70 | BTK (0.51) | JAK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110301155-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-08 | — | — | US | disclosed |
| US-20110301155-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-08 | — | — | US | disclosed |
| US-20110301155-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-08 | — | — | US | disclosed |
| EP-2157859-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | Takeda Pharmaceutical Company Limited (JP) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008156757-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008156757-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301155-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | GCKR, GCK, KHK | JAK2 655/4885PDPK1 435/4885TYK2 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.