Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 9/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26617785 | 0.93 | OPRK1 (0.47) | THRBSCN10AOPRK1ALDH1A1KDM4E | |
| SCHEMBL31105769 | 0.86 | KDM4E (0.48) | SCN10AOPRK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL31105737 | 0.85 | MEN1 (0.47) | OPRK1ALDH1A1KDM4ENPSR1MEN1 | |
| SCHEMBL26617671 | 0.85 | SCN10A (0.44) | SCN10A | |
| SCHEMBL31105854 | 0.84 | OPRK1 (0.44) | SCN10AOPRK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL26731562 | 0.83 | SCN10A (0.41) | SCN10AKDM4E | |
| SCHEMBL30681905 | 0.83 | MEN1 (0.44) | SCN10AOPRK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL26617818 | 0.83 | MEN1 (0.44) | SCN10AOPRK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL30681956 | 0.83 | MEN1 (0.45) | SCN10AOPRK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL26618040 | 0.83 | MEN1 (0.45) | SCN10AOPRK1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4514789-A1 | <SUP2/>? <SUB2/>?V?BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA1.8 FOR THE TREATMENT OF PAIN | SiteOne Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |