Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.52 |
| ▸ | CES1 | P23141 | 4/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 7/20 | 0.50 |
| ▸ | PPARD | Q03181 | 7/20 | 0.50 |
| ▸ | PPARA | Q07869 | 7/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28951891 | 0.95 | CES2 (0.52) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL5907427 | 0.87 | CES2 (0.48) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL10524282 | 0.86 | FABP3 (0.62) | PPARGPPARDPPARAPTPN1TDP1 | |
| Hydrochloric Acid SCHEMBL9705852 | 0.85 | FABP3 (0.61) | PPARGPPARDPPARAPTPN1TDP1 | |
| SCHEMBL455072 | 0.84 | CES2 (0.45) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL457603 | 0.84 | CES2 (0.45) | CES2CES1GPR84PPARGPPARD | |
| Hydrochloric Acid SCHEMBL16538158 | 0.82 | CES2 (0.43) | CES2CES1GPR84PPARGPPARD | |
| Bromide SCHEMBL11380808 | 0.81 | CES2 (0.56) | CES2CES1GPR84PPARGPPARD | |
| Hydrochloric Acid SCHEMBL28933231 | 0.81 | CES2 (0.42) | CES2CES1GPR84PPARGPPARD | |
| SCHEMBL28344407 | 0.81 | MAPT (0.46) | CES2CES1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250319035-A1 | CATIONIC LIPID NANOPARTICLE HAVING HIGH TRANSFECTION EFFICIENCY AND PREPARATION METHOD THEREFOR | TONG, Shuwen (CN) | 2025-10-16 | — | — | US | disclosed |
| CN-119913209-A | Composition for delivering nucleic acid into cells | 苏州多纳医药科技有限公司 | 2025-05-02 | — | — | CN | disclosed |
| CN-119896747-A | Calcium-containing lipid nanoparticle loaded with transthyretin nucleic acid for reducing transthyretin | 苏州多纳医药科技有限公司 | 2025-04-29 | — | — | CN | disclosed |
| CN-119365189-A | Cationic lipid nanoparticle with high transfection efficiency and preparation method thereof | 北京多纳医药科技有限公司 | 2025-01-24 | — | — | CN | disclosed |
| WO-2023208076-A1 | CATIONIC LIPID NANOPARTICLE HAVING HIGH TRANSFECTION EFFICIENCY AND PREPARATION METHOD THEREFOR | 北京多纳医药科技有限公司 | 2023-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250319035-A1 | CATIONIC LIPID NANOPARTICLE HAVING HIGH TRANSFECTION EFFICIENCY AND PREPARATION METHOD THEREFOR | CETP, NPC1L1, LIPA | CES2 945/4885CES1 78/4885GPR84 3916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.