Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451595 | 0.85 | CFTR (0.48) | NAPRTSMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL771190 | 0.82 | KDM4E (0.46) | NAPRTSMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL30137058 | 0.81 | CFTR (0.46) | SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27455320 | 0.80 | NAPRT (0.43) | NAPRTSMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL27445792 | 0.79 | NAPRT (0.50) | NAPRTSMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL5147826 | 0.79 | SMN1; SMN2 (0.53) | NAPRTSMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL28179698 | 0.78 | NAPRT (0.48) | NAPRTSMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL1645022 | 0.76 | HPGD (0.43) | SLC6A2SLC6A4SLC6A3L3MBTL1KDM4E | |
| SCHEMBL248500 | 0.76 | SRC (0.54) | SMN1; SMN2LMNAKDM4EPOLBMAPT | |
| SCHEMBL3398714 | 0.76 | SRC (0.54) | SMN1; SMN2LMNAKDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874758-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111516-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-10-26 | — | — | WO | disclosed |