Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662424 | 0.94 | FFAR1 (0.38) | SIRT2FFAR1 | |
| SCHEMBL1342940 | 0.88 | FFAR1 (0.38) | SIRT2MAPK14KMT2AKDM4ELMNA | |
| SCHEMBL1343648 | 0.87 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL1343806 | 0.84 | SIRT2 (0.39) | SIRT2MAPK14KMT2AKDM4ELMNA | |
| SCHEMBL2649004 | 0.83 | POLB (0.36) | SIRT2MAPK14KMT2ALMNATP53 | |
| SCHEMBL6697415 | 0.82 | HTT (0.41) | SIRT2KMT2ALMNAHTTMAPT | |
| SCHEMBL1340678 | 0.82 | ITGB1 (0.41) | SIRT2KMT2AKDM4ELMNAMAPT | |
| SCHEMBL1342714 | 0.82 | SMN1; SMN2 (0.45) | SIRT2KMT2AKDM4ELMNATP53 | |
| SCHEMBL1342415 | 0.82 | MAPK14 (0.41) | SIRT2MAPK14KMT2ALMNAMAPK13 | |
| SCHEMBL1342171 | 0.80 | MYC (0.43) | RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |