Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915529 | 0.86 | NPSR1 (0.37) | MAPK1CA1CA9NPSR1TSHR | |
| SCHEMBL2661782 | 0.86 | NPSR1 (0.40) | NPSR1TSHR | |
| SCHEMBL4917712 | 0.78 | MEN1 (0.32) | CA1CA9 | |
| SCHEMBL4917709 | 0.78 | MEN1 (0.32) | CA1CA9 | |
| SCHEMBL17185241 | 0.69 | ALDH1A1 (0.33) | MAPK1 | |
| SCHEMBL21341572 | 0.65 | CA1 (0.34) | CA1CA9 | |
| SCHEMBL2657547 | 0.62 | CA1 (0.35) | CA1CA9NPSR1 | |
| SCHEMBL21341851 | 0.61 | CA1 (0.34) | CA1CA9 | |
| SCHEMBL4921842 | 0.60 | ALDH1A1 (0.34) | CA1CA9TSHR | |
| SCHEMBL852748 | 0.59 | MAPK1 (0.40) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176263-A2 | FUSED QUINOLINE DERIVATIVES USEFUL AS GABA MODULATORS | AstraZeneca AB (SE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2008155572-A2 | FUSED QUINOLINE DERIVATIVES USEFUL AS GABA MODULATORS | ASTRAZENECA AB (SE) | 2008-12-24 | — | — | WO | disclosed |