Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689367 | 0.86 | CTNNB1 (0.68) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| SCHEMBL6368241 | 0.81 | CTNNB1 (0.74) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| Methyl Alcohol SCHEMBL8782982 | 0.80 | CTNNB1 (0.93) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| SCHEMBL27680126 | 0.80 | CTNNB1 (1.00) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| SCHEMBL5724 | 0.80 | CTNNB1 (1.00) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| SCHEMBL28876495 | 0.80 | CTNNB1 (1.00) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| SCHEMBL14030895 | 0.79 | HTT (0.68) | PTGS2MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL1892492 | 0.79 | CTNNB1 (0.77) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| SCHEMBL27800575 | 0.79 | CTNNB1 (0.77) | CTNNB1IRAK4MEN1KMT2ANR1I2 | |
| SCHEMBL16041713 | 0.79 | BRD4 (0.78) | CTNNB1PTGS2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027113-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | AstraZeneca AB (SE) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007007042-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| CN-1777589-A | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMA CO LTD (JP) | 2006-05-24 | — | — | CN | disclosed |