Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25202448 | 1.00 | LRRK2 (0.43) | LRRK2ALKIGF1RCCR2 | |
| SCHEMBL25227805 | 1.00 | LRRK2 (0.43) | LRRK2ALKIGF1RCCR2 | |
| SCHEMBL30411855 | 0.93 | LRRK2 (0.45) | LRRK2ALK | |
| SCHEMBL25224704 | 0.93 | LRRK2 (0.45) | LRRK2ALK | |
| SCHEMBL30412450 | 0.89 | ALK (0.43) | LRRK2ALK | |
| SCHEMBL30410928 | 0.89 | ALK (0.43) | LRRK2ALK | |
| SCHEMBL25198593 | 0.89 | PTK2 (0.40) | LRRK2ALK | |
| SCHEMBL26629481 | 0.89 | PTK2 (0.40) | LRRK2ALK | |
| SCHEMBL26629380 | 0.88 | ALK (0.40) | LRRK2ALK | |
| SCHEMBL25222599 | 0.88 | LRRK2 (0.43) | LRRK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |