Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 4/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25198593 | 1.00 | PTK2 (0.40) | PTK2FLT4ALKLRRK2ULK1 | |
| SCHEMBL26629380 | 0.90 | ALK (0.40) | PTK2FLT4ALKLRRK2JAK1 | |
| SCHEMBL30635595 | 0.90 | ALK (0.43) | PTK2FLT4ALKLRRK2 | |
| SCHEMBL30412718 | 0.90 | ALK (0.43) | PTK2FLT4ALKLRRK2 | |
| SCHEMBL26629332 | 0.89 | PTK2 (0.39) | PTK2FLT4ALKLRRK2ULK1 | |
| SCHEMBL25236453 | 0.89 | PTK2 (0.39) | PTK2FLT4ALKLRRK2ULK1 | |
| SCHEMBL25227805 | 0.89 | LRRK2 (0.43) | ALKLRRK2 | |
| SCHEMBL25202448 | 0.89 | LRRK2 (0.43) | ALKLRRK2 | |
| SCHEMBL26629467 | 0.89 | LRRK2 (0.43) | ALKLRRK2 | |
| SCHEMBL26629378 | 0.85 | TYK2 (0.39) | PTK2FLT4ALKLRRK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |