Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 15/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2663719 | 0.87 | HPGDS (0.47) | HPGDSGCKKCNH2NPC1RAB9A | |
| SCHEMBL10253435 | 0.86 | NPC1 (0.55) | HPGDSGCKKCNH2NPC1RAB9A | |
| SCHEMBL2663742 | 0.86 | HPGDS (0.43) | HPGDSGCKKCNH2NPC1RAB9A | |
| SCHEMBL645436 | 0.83 | GCK (0.54) | HPGDSGCKKCNH2 | |
| SCHEMBL2663749 | 0.83 | NPC1 (0.43) | HPGDSGCKNPC1RAB9A | |
| SCHEMBL2663722 | 0.83 | HPGDS (0.47) | HPGDSGCKKCNH2NPC1RAB9A | |
| SCHEMBL2663726 | 0.82 | HPGDS (0.47) | HPGDSGCKKCNH2NPC1RAB9A | |
| SCHEMBL2663739 | 0.81 | HPGDS (0.42) | HPGDSGCKKCNH2NPC1RAB9A | |
| SCHEMBL2663747 | 0.81 | HPGDS (0.43) | HPGDSGCKKCNH2NPC1RAB9A | |
| SCHEMBL2663767 | 0.80 | HPGDS (0.46) | HPGDSGCKKCNH2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842713-B2 | Fused phenyl amido heterocyclic compounds | PFIZER INC (US) | 2010-11-30 | — | — | US | disclosed |
| US-20080280875-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280875-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS | GCK, GCKR, HK1 | HPGDS 2875/4885GCK 1/4885KCNH2 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.