Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26638240 | 1.00 | LMNA (0.46) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL26638111 | 0.91 | LMNA (0.47) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL26638112 | 0.91 | LMNA (0.47) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL26638191 | 0.85 | LMNA (0.45) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL26638193 | 0.85 | LMNA (0.45) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL22805428 | 0.85 | LMNA (0.42) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL22805429 | 0.85 | LMNA (0.42) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL26638048 | 0.84 | LMNA (0.47) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL26638054 | 0.84 | LMNA (0.47) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 | |
| SCHEMBL22805210 | 0.83 | LMNA (0.49) | LMNAKMT2AMEN1SMN1; SMN2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986873-B9 | 5-[(1S)-1-(4-BROMOPHENOXY)ETHYL]-2H-TETRAZOLE DERIVATIVES AND RELATED COMPOUNDS AS CLC-1 ION CHANNEL INHIBITORS FOR TREATING NEUROMUSCULAR DISORDERS | NMD PHARMA AS (DK) | 2024-05-29 | — | — | EP | claimed |
| EP-3986873-B1 | 5-[(1S)-1-(4-BROMOPHENOXY)ETHYL]-2H-TETRAZOLE DERIVATIVES AND RELATED COMPOUNDS AS CLC-1 ION CHANNEL INHIBITORS FOR TREATING NEUROMUSCULAR DISORDERS | NMD PHARMA AS (DK) | 2023-11-15 | — | — | EP | claimed |