Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | NQO2 | P16083 | 6/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30657473 | 1.00 | KDM4E (0.50) | KDM4EPOLBGAANQO2ABL1 | |
| SCHEMBL25130936 | 0.85 | POLB (0.44) | KDM4EPOLBNQO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL25130856 | 0.85 | KDM4E (0.38) | KDM4EPOLBGAANQO2ALDH1A1 | |
| SCHEMBL29678780 | 0.83 | KDM4E (0.53) | KDM4EPOLBGAANQO2ABL1 | |
| SCHEMBL110643 | 0.83 | KDM4E (0.53) | KDM4EPOLBGAANQO2ABL1 | |
| SCHEMBL6560149 | 0.82 | KDM4E (0.51) | KDM4EPOLBGAANQO2ALDH1A1 | |
| SCHEMBL535539 | 0.82 | KDM4E (0.51) | KDM4EPOLBGAANQO2ABL1 | |
| SCHEMBL31039239 | 0.82 | KDM4E (0.51) | KDM4EPOLBGAANQO2ABL1 | |
| SCHEMBL536169 | 0.81 | KDM4E (0.50) | KDM4EPOLBGAANQO2ABL1 | |
| SCHEMBL17979068 | 0.81 | KDM4E (0.50) | KDM4EPOLBGAANQO2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215256-A1 | SOS1 INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023215256-A1 | SOS1 INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |