Sugi Predict

Sugi Predict / Compounds / SCHEMBL536169

SCHEMBL536169

SCHEMBL536169

COC(=O)c1cc(Cl)nc(Br)c1N

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.50
▸ NQO2 P16083 7/20 0.46
▸ ABL1 P00519 1/20 0.45
▸ POLB P06746 1/20 0.44
▸ GAA P10253 3/20 0.43
▸ ALDH1A1 P00352 3/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ HPGD P15428 2/20 0.39
▸ GLA P06280 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ CASP1 P29466 1/20 0.39
▸ CASP7 P55210 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ TUBB4A P04350 1/20 0.39
▸ TUBB P07437 1/20 0.39
▸ TUBA3C P0DPH7 1/20 0.39
▸ TUBA1B P68363 1/20 0.39
▸ TUBA4A P68366 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31264183 0.83 KDM4E (0.46) KDM4ENQO2ABL1POLBGAA
SCHEMBL143872 0.83 KDM4E (0.46) KDM4ENQO2ABL1POLBGAA
SCHEMBL110643 0.83 KDM4E (0.53) KDM4ENQO2ABL1POLBGAA
SCHEMBL29678780 0.83 KDM4E (0.53) KDM4ENQO2ABL1POLBGAA
SCHEMBL17840873 0.83 KDM4E (0.44) KDM4EGAAALDH1A1SMN1; SMN2HSD17B10
SCHEMBL30641332 0.83 KDM4E (0.44) KDM4EGAAALDH1A1SMN1; SMN2HSD17B10
SCHEMBL25360994 0.82 KDM4E (0.54) KDM4ENQO2POLBGAAALDH1A1
SCHEMBL535539 0.82 KDM4E (0.51) KDM4ENQO2ABL1POLBGAA
SCHEMBL31039239 0.82 KDM4E (0.51) KDM4ENQO2ABL1POLBGAA
SCHEMBL25360740 0.81 CFTR (0.41) KDM4EGAASMN1; SMN2CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026087634-A1 TREM2 AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2026-04-30 — — WO disclosed
WO-2025101598-A1 BI-CYCLIC PYRIMIDINE COMPOUNDS, METHODS AND USES THEREOF ZENO MANAGEMENT, INC. (US) 2025-05-15 — — WO disclosed
CN-118666737-A Phenol derivative, pharmaceutical composition containing same, preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2024-09-20 — — CN disclosed
CN-114644627-B AhR inhibitors and uses thereof 山东轩竹医药科技有限公司 2024-06-11 — — CN disclosed
CN-114181208-B Tri-fused ring AhR inhibitor and application thereof 山东轩竹医药科技有限公司 2023-05-02 — — CN disclosed
WO-2023051628-A1 SOS1 INHIBITORS HAVING PYRIDO SIX-MEMBERED RING STRUCTURE 上海海和药物研究开发股份有限公司 2023-04-06 — — WO disclosed
US-20230025807-A1 CD38 INHIBITORS Astellas Engineered Small Molecules US, Incorporated 2023-01-26 — — US disclosed
US-20230025807-A1 CD38 INHIBITORS Astellas Engineered Small Molecules US, Incorporated 2023-01-26 — — US disclosed
CN-115636828-A Tricyclic AhR inhibitors 山东轩竹医药科技有限公司 2023-01-24 — — CN disclosed
CN-114644627-A AhR inhibitor and application thereof 山东轩竹医药科技有限公司 2022-06-21 — — CN disclosed
US-8247431-B2 Heterocyclic hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-21 — — US disclosed
US-8247431-B2 Heterocyclic hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-21 — — US disclosed
EP-2144898-B1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2012-02-08 — — EP disclosed
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 — — US disclosed
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 — — US disclosed
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 — — US disclosed
CN-101679377-A Heterocyclic hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO 2010-03-24 — — CN disclosed
EP-2144898-A2 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2010-01-20 — — EP disclosed
WO-2008130021-A2 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-10-30 — — WO disclosed
WO-2008130021-A2 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-10-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230025807-A1 CD38 INHIBITORS CD38, GLS, IDH2 KDM4E 939/4885NQO2 28/4885ABL1 1128/4885
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, CAT, DNPH1 KDM4E 2297/4885NQO2 65/4885ABL1 3184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.