Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 3/20 | 0.51 |
| ▸ | MARK4 | Q96L34 | 3/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.51 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.50 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | STK16 | O75716 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.49 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30648664 | 1.00 | CDK1 (0.54) | CDK1KDRMARK3MARK4STK17A | |
| SCHEMBL26640668 | 0.89 | PLK1 (0.53) | CDK1TBK1CDK2AURKACDK5 | |
| SCHEMBL30648695 | 0.89 | PLK1 (0.53) | CDK1TBK1CDK2AURKACDK5 | |
| SCHEMBL26640962 | 0.88 | AURKA (0.50) | PLK4CDK2AURKACCNA2CCNA1 | |
| SCHEMBL26640849 | 0.80 | CDK5 (0.48) | CDK1CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL30648678 | 0.80 | CDK5 (0.48) | CDK1CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL30648712 | 0.79 | CDK5 (0.55) | CDK1KDRCDK2AURKACDK5 | |
| SCHEMBL26640527 | 0.79 | CDK5 (0.55) | CDK1KDRCDK2AURKACDK5 | |
| SCHEMBL26640771 | 0.79 | GRM5 (0.50) | CDK1KDRPLK4CDK2CDK5 | |
| SCHEMBL30648740 | 0.78 | CDK5 (0.54) | CDK1KDRCDK2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| US-20240025922-A1 | TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS | MERCK HEALTHCARE KGAA (DE) | 2024-01-25 | — | — | US | disclosed |
| US-20240025922-A1 | TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS | MERCK HEALTHCARE KGAA (DE) | 2024-01-25 | — | — | US | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025922-A1 | TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS | PDXK, DTYMK, HIPK1 | CDK1 248/4885KDR 3071/4885MARK3 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.