SCHEMBL26643304

SCHEMBL26643304

COc1ccc(/C=C/c2cccc(C(=O)O)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 3/20 0.67
SNCA P37840 1/20 0.65
RELA Q04206 6/20 0.63
TRPA1 O75762 1/20 0.61
BCHE P06276 2/20 0.59
NFKB1 P19838 2/20 0.59
NFKB2 Q00653 2/20 0.59
CYP3A4 P08684 1/20 0.59
NFE2L2 Q16236 2/20 0.58
APP P05067 1/20 0.58
XDH P47989 1/20 0.57
MAOB P27338 3/20 0.55
MEN1 O00255 1/20 0.55
ALDH1A1 P00352 1/20 0.55
MAPT P10636 1/20 0.55
HSPD1 P10809 1/20 0.55
TNFRSF1A P19438 1/20 0.55
HSPE1 P61604 1/20 0.55
KMT2A Q03164 1/20 0.55
CYP1B1 Q16678 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31516468 1.00 TTR (0.67) TTRSNCARELATRPA1BCHE
SCHEMBL2400804 0.89 BCHE (0.68) TTRRELABCHECYP3A4NFE2L2
SCHEMBL2400795 0.89 BCHE (0.68) TTRRELABCHECYP3A4NFE2L2
SCHEMBL13926057 0.87 TTR (0.86) TTR
SCHEMBL22887494 0.86 SNCA (0.64) SNCARELATRPA1BCHENFKB1
SCHEMBL31516513 0.86 SNCA (0.64) SNCARELATRPA1BCHENFKB1
SCHEMBL25195133 0.85 MAOB (0.77) RELABCHENFKB1NFKB2CYP3A4
SCHEMBL30382414 0.85 MAOB (0.77) RELABCHENFKB1NFKB2CYP3A4
SCHEMBL25191354 0.85 MAOB (0.77) RELABCHENFKB1NFKB2CYP3A4
SCHEMBL2400852 0.84 RELA (0.68) SNCARELABCHENFE2L2APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250313546-A1 NUCLEIC ACID BINDERS UNIVERSITY OF STRATHCLYDE (GB) 2025-10-09 US disclosed
EP-4522588-A1 NUCLEIC ACID BINDERS University of Strathclyde (GB) 2025-03-19 EP disclosed
WO-2023218194-A1 NUCLEIC ACID BINDERS UNIVERSITY OF STRATHCLYDE (GB) 2023-11-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250313546-A1 NUCLEIC ACID BINDERS ZFR, NSUN3, POLI TTR 2593/4885SNCA 3491/4885RELA 1882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.