SCHEMBL2664352

SCHEMBL2664352

COc1cc(/C=N/NS(=O)(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.76

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GCGR P47871 13/20 0.76
ADCYAP1R1 P41586 5/20 0.57
NPC1 O15118 2/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPT P10636 2/20 0.47
RAB9A P51151 2/20 0.47
MITF O75030 1/20 0.47
PAX8 Q06710 1/20 0.46
GFER P55789 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2664178 0.86 GCGR (1.00) GCGRADCYAP1R1
SCHEMBL9072211 0.83 GCGR (1.00) GCGRADCYAP1R1
SCHEMBL2664351 0.80 GCGR (0.71) GCGRNPC1ALDH1A1MAPTRAB9A
SCHEMBL7228850 0.75 GCGR (0.57) GCGRADCYAP1R1MAPT
SCHEMBL2663824 0.74 GCGR (0.83) GCGRADCYAP1R1
SCHEMBL2663822 0.74 GCGR (0.83) GCGRADCYAP1R1
SCHEMBL2664121 0.72 GCGR (0.80) GCGRADCYAP1R1
SCHEMBL2664360 0.72 GCGR (0.74) GCGRADCYAP1R1
SCHEMBL2663720 0.72 GCGR (0.55) GCGRNPC1ALDH1A1MAPTRAB9A
SCHEMBL2663870 0.71 ADCYAP1R1 (0.88) GCGRADCYAP1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999001423-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 1999-01-14 WO disclosed