Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623055 | 1.00 | BRAF (0.38) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL26645629 | 0.99 | BRAF (0.38) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL26645634 | 0.99 | BRAF (0.38) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL30622948 | 0.99 | BRAF (0.38) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL26645870 | 0.86 | BCHE (0.40) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| Hydrochloric Acid SCHEMBL26645351 | 0.85 | BCHE (0.39) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| Hydrochloric Acid SCHEMBL26645469 | 0.85 | BCHE (0.39) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| Hydrochloric Acid SCHEMBL26645347 | 0.85 | BCHE (0.39) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| Hydrochloric Acid SCHEMBL26645642 | 0.85 | BCHE (0.39) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| Hydrochloric Acid SCHEMBL26645444 | 0.85 | BCHE (0.39) | MAPK14MAPK13MAPK12MAPK11TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |