Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL26645469 | 1.00 | BCHE (0.39) | BCHEMAPK14MAPK11MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL26645444 | 1.00 | BCHE (0.39) | BCHEMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL26645870 | 0.99 | BCHE (0.40) | BCHEMAPK14MAPK11MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL26645642 | 0.98 | BCHE (0.39) | BCHEMAPK14MAPK11MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL26645445 | 0.98 | BCHE (0.39) | BCHEMAPK14MAPK11MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL26645351 | 0.98 | BCHE (0.39) | BCHEMAPK14MAPK11MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL26645687 | 0.86 | MAPK14 (0.35) | MAPK14MAPK11RIPK3CSNK1ETGFBR1 | |
| Hydrochloric Acid SCHEMBL26645629 | 0.86 | BRAF (0.38) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL30623055 | 0.85 | BRAF (0.38) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL26645174 | 0.85 | BRAF (0.38) | MAPK14MAPK11MAPK13MAPK12RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |