Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30622877 | 0.98 | SRC (0.44) | SRCBRAFKDRTGFBR1GAA | |
| Hydrochloric Acid SCHEMBL26645396 | 0.98 | SRC (0.44) | SRCBRAFKDRTGFBR1GAA | |
| Hydrochloric Acid SCHEMBL30622880 | 0.84 | MAPK14 (0.50) | SRCBRAFKDRMAPK14MAPK11 | |
| Hydrochloric Acid SCHEMBL26645654 | 0.84 | MAPK14 (0.50) | SRCBRAFKDRMAPK14MAPK11 | |
| SCHEMBL26645403 | 0.81 | MAPK9 (0.48) | TGFBR1MAPK14MAPK11ALOX5 | |
| Hydrochloric Acid SCHEMBL26645017 | 0.78 | BRAF (0.47) | SRCBRAFKDRTGFBR1MAPK14 | |
| SCHEMBL26645167 | 0.78 | SRC (0.43) | SRCBRAFKDRTGFBR1GAA | |
| Hydrochloric Acid SCHEMBL26645438 | 0.77 | BRD4 (0.36) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL26645571 | 0.76 | BRAF (0.43) | SRCBRAFKDRTGFBR1GAA | |
| Hydrochloric Acid SCHEMBL30622810 | 0.76 | BRAF (0.47) | SRCBRAFKDRTGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |