Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 12/20 | 0.61 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.61 |
| ▸ | BCL2L1 | Q07817 | 9/20 | 0.56 |
| ▸ | HTR7 | P34969 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1955694 | 0.90 | BCL2 (0.58) | BCL2BAK1BCL2L1HTR7KDM4E | |
| SCHEMBL1957837 | 0.89 | BCL2 (0.57) | BCL2BAK1BCL2L1HTR7KDM4E | |
| SCHEMBL1743533 | 0.87 | HTR7 (0.66) | BCL2BAK1BCL2L1HTR7KDM4E | |
| SCHEMBL26647735 | 0.87 | BCL2 (0.49) | BCL2BAK1BCL2L1KDM4ELMNA | |
| SCHEMBL1742359 | 0.86 | BCL2 (0.55) | BCL2BAK1BCL2L1HTR7KDM4E | |
| SCHEMBL26648406 | 0.85 | BCL2 (0.46) | BCL2BAK1BCL2L1KDM4ELMNA | |
| SCHEMBL1743053 | 0.85 | BCL2 (0.54) | BCL2BAK1BCL2L1HTR7 | |
| SCHEMBL1741405 | 0.85 | BCL2 (0.71) | BCL2BAK1BCL2L1HTR7KDM4E | |
| SCHEMBL29846744 | 0.85 | BCL2 (0.71) | BCL2BAK1BCL2L1HTR7KDM4E | |
| SCHEMBL1956951 | 0.84 | BCL2 (0.61) | BCL2BCL2L1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220425-A1 | BCL-XL/BCL-2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |