SCHEMBL26650694

SCHEMBL26650694

Nc1ncc2cc(NC(=O)c3ccc(NS(=O)(=O)CCO)cc3N3CCC4(CC3)CC4)cc(N3CCC(F)(F)CC3)c2n1

nearest known ligand 0.70

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30748626 1.00 KIF18A (0.70) KIF18A
SCHEMBL26650617 0.88 KIF18A (0.72) KIF18A
SCHEMBL30748649 0.88 KIF18A (0.72) KIF18A
SCHEMBL30748630 0.87 KIF18A (0.67) KIF18A
SCHEMBL26650700 0.87 KIF18A (0.67) KIF18A
SCHEMBL26650308 0.87 KIF18A (0.68) KIF18A
SCHEMBL30748598 0.87 KIF18A (0.68) KIF18A
SCHEMBL26651075 0.86 KIF18A (0.72) KIF18A
SCHEMBL31485278 0.86 KIF18A (0.69) KIF18A
SCHEMBL26650743 0.86 KIF18A (0.69) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023217230-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF 上海湃隆生物科技有限公司 2023-11-16 — — WO disclosed
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