Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.39 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642017 | 1.00 | SLC6A3 (0.40) | SLC6A3LMNAPTGS1PTGS2MT-CO1 | |
| SCHEMBL2646333 | 0.85 | KCNH2 (0.47) | SLC6A3LMNAKCNQ2SLC6A2SLC6A4 | |
| SCHEMBL2646335 | 0.85 | KCNH2 (0.47) | SLC6A3LMNAKCNQ2SLC6A2SLC6A4 | |
| SCHEMBL2645000 | 0.84 | SLC6A3 (0.46) | SLC6A3LMNAKCNQ2SLC6A2SLC6A4 | |
| SCHEMBL2642846 | 0.81 | SLC6A3 (0.55) | SLC6A3PTGS1PTGS2MT-CO1MT-CO2 | |
| SCHEMBL2642359 | 0.81 | SLC6A3 (0.37) | SLC6A3LMNAKCNQ2SLC6A2SLC6A4 | |
| SCHEMBL2659373 | 0.81 | SLC6A3 (0.37) | SLC6A3LMNAKCNQ2SLC6A2SLC6A4 | |
| SCHEMBL14423126 | 0.81 | SLC6A3 (0.39) | SLC6A3LMNAPTGS1PTGS2KCNQ2 | |
| SCHEMBL2642424 | 0.81 | SLC6A3 (0.39) | SLC6A3LMNAPTGS1PTGS2KCNQ2 | |
| SCHEMBL2642147 | 0.81 | SLC6A3 (0.44) | SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105671-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2006-09-12 | — | — | US | claimed |
| US-7259166-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259166-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| WO-2003095438-A9 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-12-23 | — | — | WO | disclosed |
| WO-2003095438-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-20 | — | — | WO | disclosed |