Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 10/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | STK25 | O00506 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9072563 | 0.88 | GCK (0.40) | GCKKCNH2STK25 | |
| SCHEMBL9072612 | 0.87 | GCK (0.46) | GCKKCNH2 | |
| SCHEMBL2665290 | 0.84 | GCK (0.51) | GCKKMT2APIK3CAPRKDCPTGS2 | |
| SCHEMBL2665310 | 0.82 | GCK (0.49) | GCKKMT2APIK3CAPRKDCPTGS2 | |
| SCHEMBL9072561 | 0.82 | GCK (0.49) | GCKKMT2APIK3CAPRKDCAKR1C3 | |
| SCHEMBL2665325 | 0.81 | GCK (0.48) | GCKKMT2APIK3CAPRKDCPTGS2 | |
| SCHEMBL2665295 | 0.80 | GCK (0.57) | GCKKMT2APIK3CAPRKDCKCNH2 | |
| SCHEMBL2022862 | 0.76 | GCK (0.48) | GCKKMT2APTGS2AKR1C3KCNH2 | |
| SCHEMBL2022861 | 0.76 | GCK (0.48) | GCKKMT2APTGS2AKR1C3KCNH2 | |
| SCHEMBL2646021 | 0.76 | GCK (0.83) | GCKKMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132425-B2 | 5-substituted-six-membered heteroaromatic glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2006-11-07 | — | — | US | disclosed |