Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2665299 | 0.88 | GCK (0.44) | GCKKCNH2 | |
| SCHEMBL9072572 | 0.87 | GCK (0.43) | GCKKCNH2 | |
| SCHEMBL2665290 | 0.80 | GCK (0.51) | GCKKMT2AKCNH2ATRPIK3CA | |
| SCHEMBL2665286 | 0.80 | GCK (0.51) | GCKKMT2AKCNH2ATRPIK3CA | |
| SCHEMBL2665310 | 0.78 | GCK (0.49) | GCKKMT2AKCNH2ATRPIK3CA | |
| SCHEMBL9072561 | 0.78 | GCK (0.49) | GCKKMT2AKCNH2PIK3CAPRKDC | |
| SCHEMBL2665325 | 0.77 | GCK (0.48) | GCKKMT2AKCNH2ATRPIK3CA | |
| SCHEMBL2646024 | 0.73 | GCK (0.83) | GCKKMT2AKCNH2 | |
| SCHEMBL2646021 | 0.73 | GCK (0.83) | GCKKMT2AKCNH2 | |
| SCHEMBL2660006 | 0.73 | GCK (1.00) | GCKKMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132425-B2 | 5-substituted-six-membered heteroaromatic glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2006-11-07 | — | — | US | disclosed |